Panagiotis Simos was born in 1967 in Athens. He studied Experimental Psychology–Biopsychology at Southern Illinois University (1995, MA, PhD) and specialized in Clinical Neurophysiology and Functional Brain Imaging at the Department of Neurosurgery, University of Texas at Houston (1996). There, he served as Associate Professor and member of the Clinical Neuroscience Division, conducting intraoperative electrophysiological monitoring as well as preoperative mapping of cortical regions responsible for language functions and epileptogenic zones using Magnetoencephalography (MEG) (1996–2003).

In 2003, he was appointed Associate Professor and in 2008 Professor in the Department of Psychology at the University of Crete, where he also served as Associate Chair and Director of the Graduate Program in School Psychology and Health Psychology. Since 2010, he has been a Professor in the Department of Psychiatry and Behavioral Sciences at the Medical School of the University of Crete and Head of the Neuropsychology Clinic at the University General Hospital of Heraklion (PGNH). Since 2014, he has also been a Collaborating Researcher at the Laboratory of Computational Biomedicine, Institute of Computer Science, Foundation for Research and Technology – Hellas (ICS-FORTH).